Search results for "Drug uptake"

Cellular uptake and in vitro antitumor efficacy of composite liposomes for neutron capture therapy.

2014

Background Neutron capture therapy for glioblastoma has focused mainly on the use of 10B as neutron capture isotope. However, 157Gd offers several advantages over boron, such as higher cross section for thermal neutrons and the possibility to perform magnetic resonance imaging during neutron irradiation, thereby combining therapy and diagnostics. We have developed different liposomal formulations of gadolinium-DTPA (Magnevist®) for application in neutron capture therapy of glioblastoma. The formulations were characterized physicochemically and tested in vitro in a glioma cell model for their effectiveness. Methods Liposomes entrapping gadolinium-DTPA as neutron capture agent were manufactur…